Endocrine Abstracts

Case summary: A 40 year-old lady, who has a background of asthma, presented to emergency department with back pain radiated down to her left leg with associated foot drop. She also complained of 2 months history of weight gain, hirsutism, and menstrual disturbance. Clinical examination confirmed that she had some cushingoid features. Further assessment and investigations revealed that she had acute disc prolapse on MRI as well as an incidental finding of right adrenal gland an...

Introduction: Hypercalcemia has been described in patients with granulomatous disorders. Most commonly sarcoidosis (10% of patients) and tuberculosis with three-fold increase in hypercalciuria. It’s due to production of calcidiol from calcitriol in the lung and lymph nodes that is independent of PTH. Main modalities of therapy are low-calcium diet, glucocorticoids, and treatment of the underlying disease.The Case: A 48-year-old male, referred to end...

Background: Hypothyroidism is a common disorder presenting with both somatic and psychiatric symptoms. Two cases of late onset psychosis are presented as an initial manifestation of myxedema.Case presentation: 1. An 80-year old woman who had no past medical history presented with auditory and persecutory hallucinations. During her hospital stay she was found to have a decreased level of consciousness (GCS:4), and a blood investigation showed the presence...

Immunotherapy with immune checkpoint inhibitors has become an effective treatment of many malignancies resistant to conventional chemotherapies. Immune checkpoints are molecules on the surface of immune cells involved in the regulation of the immune response and immune checkpoint inhibitors are monoclonal antibodies directed against certain immune checkpoints, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed death 1 (PD-1) and its ligand (PD-L1), res...

Our group studies the influence of different endocrine factors on cardiovascular function. Ang II is the main vasopeptide of Renin-Angiotensin System (RAS) and exerts its potent biological effects through AT1 and AT2 receptors. In heart, Ang II induces cardiomyocyte hypertrophy and fibroblast hyperplasia through TGF-β1 recruitment. On the other hand, cardiovascular system is very sensitive to the action of the Thyroid Hormones (THs). One major cardiovascular manifestation...

Rare skeletal metabolic diseases comprise a group of diseases commonly associated with severe clinical consequences. In recent years, the description of the clinical phenotypes and radiographic features of several genetic bone disorders was paralleled by the discovery of key molecular pathways involved in the regulation of bone and mineral metabolism. Including this information in the description and classification of rare skeletal diseases may improve the recognition and mana...

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A 69 years old female with cervical radiotherapy 25 years ago for an unknown condition, known with multinodular goitre and hyperthyroidism for 6 years, presented with a 6 months history of enlarged right supraclavicular mass, local pain with difficulty in mobilization of the right arm and weight loss. She also reported progressive bilateral exophtalmia especially on the right side, no dysphagia, hoarseness or dyspnoea. Thyroid hormone levels were normal on antithyroid drugs an...

Primary aldosteronism (PA) is the most common form of secondary hypertension. In the majority of cases it is caused by unilateral aldosterone producing adenoma (APA) or by bilateral adrenal hyperplasia. Although the majority of cases of PA are sporadic, the disease may occur in the context of familial hyperaldosteronism where it is associated with specific germline mutations. Recent advances in genome technology have improved our understanding on the genetic basis of PA, allow...

Introduction and aims: Numerous studies in recent years have confirmed the existence of a link between endothelial dysfunction and vascular diseases, and lifestyle factors such as obesity, sedentary lifestyle and smoking.Methods: We examined 108 patients with obesity (90 women and 18 men, mean age 54.62±0.4 years). All patients underwent clinical and laboratory examination. Vasomotor endothelial function was evaluated by reactive hyperemia using ult...